https://www.ktbogen.com/about daily 0.75 2020-10-29 https://static1.squarespace.com/static/5a4adb8e692ebe1968e84b96/t/5a4ae0e571c10bd7b35ea919/1514856689784/Ken+Bogen.jpeg About https://www.ktbogen.com/science-advisory-boardpanel-service daily 0.75 2018-01-02 https://www.ktbogen.com/home daily 1.0 2018-01-08 https://static1.squarespace.com/static/5a4adb8e692ebe1968e84b96/t/5a4c7304ec212d8987b905d7/1515447489309/Ken+Bogen.jpeg EXPERT & CONSULTING SERVICES https://static1.squarespace.com/static/5a4adb8e692ebe1968e84b96/t/5a4adc7fe4966b19e32e68c7/1469729761345/hero_pattern.png EXPERT & CONSULTING SERVICES https://www.ktbogen.com/services daily 0.75 2018-01-07 https://www.ktbogen.com/contact daily 0.75 2018-01-04 https://static1.squarespace.com/static/5a4adb8e692ebe1968e84b96/t/5a4c72b09140b791bb2d9d3d/1514959545445/IMG_0576.JPG Contact https://www.ktbogen.com/areas-of-scientific-research-and-expertise daily 0.75 2018-01-02 https://static1.squarespace.com/static/5a4adb8e692ebe1968e84b96/t/5a4b0a07f9619ae3bb91a323/1514867224951/ARE+bla+dose-response+detail.png KEY Areas of Figure 1. Re-analysis of combined beta-lactamase (bla) reporter assay data on ARE activation by 9 hepatotoxic chemicals in HepG2 cells in vitro examined at 12 concentrations (~5 replicates/concentration).* Points = arithmetic mean % activity (PA), error bars = ±1 SDM (inner bars) and ±1 SD (outer bars). Dashed horizontal lines correspond to PA = 0% and 25%. Nonlinear J-shaped fit (solid curve, R^2 = 0.987) includes an initial linear slope that is significantly negative (p < 10^–4 by 2-tail t-test). Source: Bogen (2017, Dose-Response). *Study data kindly made available by Drs. M Xia and R Huang of the National Institutes of Health National Center for Advancing Translational Sciences, who are co-authors of: Shukla et al. Profiling environmental chemicals for activity in the antioxidant response element signaling pathway using a high throughput screening approach. Environ Health Perspect 2012; 120(8):1150–6. https://static1.squarespace.com/static/5a4adb8e692ebe1968e84b96/t/5a4b05260852291b76ab94a5/1514866646614/Figure+2+-+ACEDR+vs.+Ni-equiv+load+-+Revised.png KEY Areas of Figure 2. Dose response for combined ACD-elicitation risk data on Ni and five organic sensitizers (open points) using sensitizer-specific values of dermal load all scaled by corresponding ACD-eliciting potency relative to Ni (n = # points fit, N = # patients) compared to a common lognormal ACDER model fit (solid line) obtained by analysis of covariance for linear regression. Solid point indicates the EN 1811 reference dermal load for Ni of 0.5 μg/cm2. Patch test data on ACD elicited by Cr(VI) and Cr(III) (not shown) are also consistent with this model. Source: Bogen & Garry (2017). https://www.ktbogen.com/expert-designation-history-1 daily 0.75 2018-01-04 https://www.ktbogen.com/science-advisory-boardpanel-service-1 daily 0.75 2019-09-03 https://www.ktbogen.com/recent-projects daily 0.75 2019-09-03 https://static1.squarespace.com/static/5a4adb8e692ebe1968e84b96/t/5a4dc59cc8302529ed7ff312/1515046306834/LC+RR+vs+Age+and+Rn+w+cap.png Recent Projects - Figure 2. EPA-predicted relative risk (RR) of lung cancer above background rates for male ever-smokers in relation to age during which residential Rn exposure occurred and measured basement Rn concentration in pCi/L. Figure 2. EPA-predicted relative risk (RR) of lung cancer above background rates for male ever-smokers in relation to age during which residential Rn exposure occurred and measured basement Rn concentration in pCi/L. https://static1.squarespace.com/static/5a4adb8e692ebe1968e84b96/t/5a4c5b34ec212d8987b6134c/1514953589311/From+Fig+6+of+Bogen+%26+Gouveia+2008+J+Haz+Mater+A.png Recent Projects Figure 3. NARAC-model assessments of chemical toxicity hazard posed by a hypothetical atmospheric dispersion of 1000 kg of hydrogen cyanide (HCN) over a 1-hour period in an urban area in California. An assessment based on current default methodology (left panel) is compared to the assessment obtained by applying the same dispersion model to identical meteorological and release conditions using a modified approach that adjusts for impacts due to expected levels of concentration fluctuation on integrated toxic load (right panel). Both panels show the same ~120-sq-km bounding area on the same scale using the same color scheme to specify AEGL levels of potential toxic severity for a general population including susceptible individuals (red = lethal or life-threatening; orange = serious, irreversible or long-lasting; yellow = transient, non-disabling & reversible). The left panel inset shows with magnified scale the zones predicted to be potentially hazardous using the default approach. Note that the right panel’s orange zone is only slightly bigger than its red zone, and this red (potentially lethal) zone is 20 times larger than the red zone in the left panel. Source: adapted from Fig. 6 of Bogen & Gouveia (2008, J Haz Mater A). https://static1.squarespace.com/static/5a4adb8e692ebe1968e84b96/5a4b48c2ec212ddd081f01af/5a4b4bbf652deacfab117e0f/1514884037349/Figure+5-5+-+Dynamic+-+Cropped.png Recent Projects https://static1.squarespace.com/static/5a4adb8e692ebe1968e84b96/5a4b48c2ec212ddd081f01af/5a4b48c253450a63fe97ff59/1514883272356/Nasal+slices+-+Gel+%26+Olfactory.png Recent Projects